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Bristol-Myers Squibb and MTT Multantiv
Announce Non-Exclusive Licensing Agreement
for Multivariate Calibration Methodology

Pressemitteilung vom 11.12.2008 von

Bristol-Myers Squibb and MTT Multantiv Announce Non-Exclusive Licensing Agreement for Multivariate Calibration Methodology

(NEW BRUNSWICK, NJ, and OULU, FINLAND, December 11, 2008) – Bristol-Myers Squibb Company (NYSE:BMY) and MTT Multantiv Oy today announced that MTT Multantiv has granted Bristol-Myers Squibb non-exclusive licensing to its patent rights subject to U.S. Patent 6,629,041 for methods of multivariate calibration.

The methods, originally referred to as Specific Wiener Filtering but later re-named by practitioners in industry as Science-Based Calibration (SBC), can be used to calibrate multivariate measurement instruments, such as infrared spectrometers.

SBC solves or significantly reduces many of the problems traditionally associated with chemometrical calibration. Compared to prior methods, the main advantages of SBC include a reduction in the cost of calibration, often by as much as 80%; the elimination of the need to introduce artificial variation into smoothly running industrial processes; and an improvement in the quality of calibration, in particular, robustness.

In addition, specificity of response to the analyte of interest can be proven straightforwardly and from first principles; instrument selection and optimized interfacing to the process become simpler because hardware performance figures can be directly translated into user-relevant criteria of measurement accuracy; and the calibration process itself becomes fully transparent, i.e., results can be easily communicated and assessed by third-parties.

Financial and other terms of the agreement were not disclosed.

About Bristol-Myers Squibb
Bristol-Myers Squibb is a global pharmaceutical and related healthcare products company whose mission is to extend and enhance human life.

About MTT Multantiv
MTT Multantiv Oy is a privately owned company incorporated in 2008 to apply, promote and commercialize certain science-based methods of multivariate calibration and measurement. The company is located in Oulu, Finland

Bristol-Myers Squibb
Linda Jordan

MTT Multantiv
Ralf Marbach


".This event could well mark the beginning of the end of the widespread use of the so-called "statistical" calibration methods (PLS etc) which, as you may know, have long been a hurdle to the deployment of multivariate measurement instruments like infrared spectrometers.

The "scientific mother" of multivariate calibration, however, is time signal processing, not statistics. The frequency range is low, yes (e.g., 1/month = 400 nano-Hertz) but still the same advantages that are used in e.g. mobile phones can also be used in spectrometers.
For near infrared and other forms of spectrometry this means the cost of multivariate calibration can be drastically reduced, often by 80%, while at the same time increasing the quality of the result."




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